Promoters dictate termination mode
نویسندگان
چکیده
منابع مشابه
Gene promoters dictate histone occupancy within genes.
Spt6 is a transcriptional elongation factor and histone chaperone that reassembles transcribed chromatin. Genome-wide H3 mapping showed that Spt6 preferentially maintains nucleosomes within the first 500 bases of genes and helps define nucleosome-depleted regions in 5' and 3' flanking sequences. In Spt6-depleted cells, H3 loss at 5' ends correlates with reduced pol II density suggesting enhance...
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One clear hallmark of mammalian promoters is the presence of CpG islands (CGIs) at more than two-thirds of genes, whereas TATA boxes are only present at a minority of promoters. Using genome-wide approaches, we show that GC content and CGIs are major promoter elements in mammalian cells, able to govern open chromatin conformation and support paused transcription. First, we define three classes ...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2017
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg.2017.93